Publications


Journal articles of the Research Group FOR1202 "Mechanisms of Persistence of Hepatotropic Viruses"


2015

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B. Nassal M. Gut. 2015 Dec;64(12):1972-84

Virus-specific CD4+ T Cells Have Functional and Phenotypic Characteristics of Follicular T-helper Cells in Patients With Acute and Chronic HCV Infections. Raziorrouh B, Sacher K, Tawar RG, Emmerich F, Neumann-Haefelin C, Baumert TF, Thimme R, Boettler T. Gastroenterology. 2015 Nov 13. pii: S0016-5085(15)01622-4.

Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus.Bender S, Reuter A, Eberle F, Einhorn E, Binder M, Bartenschlager R. PLoS Pathog. 2015 Nov 20;11(11):e1005264.

Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor. Lempp FA, Mutz P, Lipps C, Wirth D, Bartenschlager R, Urban S. J Hepatol. 2015 Nov 11. pii: S0168-8278(15)00736-9. doi: 10.1016/j.jhep.2015.10.030. [Epub ahead of print]

DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture. Grünvogel O, Esser-Nobis K, Reustle A, Bartenschlager R, Ruggieri A, Lohmann V. J Virol. 2015 Oct 15;89(20):10548-68.

HBV-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro. Hoh A, Heeg M, Ni Y, Schuch A, Binder B, Hennecke N, Blum HE, Nassal M, Protzer U, Hofmann M, Urban S, Thimme R. J Virol. 2015 May 13. pii: JVI.00605-15. [Epub ahead of print]

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication via blockage of membranous web formation. Kusuma A, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T, Steinmann E. Hepatology. 2015 May 22. doi: 10.1002/hep.27913. [Epub ahead of print]

Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A. Hiet MS, Bauhofer O, Zayas M, Roth H, Tanaka Y, Schirmacher P, Willemsen J, Gruenvogel O, Bender S, Binder M, Lohmann V, Lotteau V, Ruggieri A, Bartenschlager R. J Hepatol. 2015 Apr 20. pii: S0168-8278(15)00298-6. doi: 10.1016/j.jhep.2015.04.015. [Epub ahead of print]

Tetramer enrichment reveals the presence of phenotypically diverse hepatitis C virus-specific CD8+ T cells in chronic infection. Nitschke K, Flecken T, Schmidt J, Gostick E, Marget M, Neumann-Haefelin C, Blum HE, Price DA, Thimme R. J Virol. 2015 Jan;89(1):25-34.

2014

Suppressive Effect of Interleukin 10 on Priming of Naive Hepatitis C Virus-Specific CD8+ T Cells. Niesen E, Schmidt J, Flecken T, Thimme R. J Infect Dis. 2014 Oct 29. pii: jiu541. [Epub ahead of print ]

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses. Koeniger C, Wingert I, Marsmann M, Roesler C, Beck J, Nassal M. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4244-53

Restoration of HBV-specific CD8+ T-cell function by PD-1 blockade in inactive carrier patients is linked to T-cell differentiation. Bengsch B, Martin B, Thimme R. J Hepatol. 2014 Jul 9. pii: S0168-8278(14)00473-5. doi: 10.1016/j.jhep.2014.07.005. [Epub ahead of print]

The role of natural killer cells and CD8(+) T cells in hepatitis B virus infection. Schuch A, Hoh A, Thimme R. Front Immunol. 2014 Jun 3;5:258. doi: 10.3389/fimmu.2014.00258. eCollection 2014. Review.

Restoration of HCV-specific CD8+ T cell function by interferon-free therapy. Martin B, Hennecke N, Lohmann V, Kayser A, Neumann-Haefelin C, Kukolj G, Böcher WO, Thimme R. J Hepatol. 2014 Sep;61(3):538-43

Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation. Madan V, Paul D, Lohmann V, Bartenschlager R. Gastroenterology. 2014 May;146(5):1361-72

Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor. Nkongolo S, Ni Y, Lempp FA, Kaufman C, Lindner T, Esser-Nobis K, Lohmann V, Mier W, Mehrle S, Urban S. J Hepatol. 2014 Apr;60(4):723-31

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes. Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Faelth M, Stindt J, Koeniger C, Nassal M, Kubitz R, Sueltmann H, Urban S. Gastroenterology. 2014 Apr;146(4):1070-1083

2013

The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection. Bartenschlager R, Lohmann V, Penin F. Nat Rev Microbiol. 2013 Jul;11(7):482-96.Review

Interferon-stimulated genes and their role in controlling hepatitis C virus. Metz P, Reuter A, Bender S, Bartenschlager R. J Hepatol. 2013 Dec;59(6):1331-41

The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus Replication. de Chassey B, Aublin-Gex A, Ruggieri A, Meyniel-Schicklin L, Pradezynski F, Davoust N, Chantier T, Tafforeau L, Mangeot PE, Ciancia C, Perrin-Cocon L, Bartenschlager R, Andre P, Lotteau V.PLoS Pathog. 2013 Jul;9(7):e1003440

Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B.Esser-Nobis K, Romero-Brey I, Ganten TM, Gouttenoire J, Harak C, Klein R, Schemmer P, Binder M, Schnitzler P, Moradpour D, Bartenschlager R, Polyak SJ, Stremmel W, Penin F, Eisenbach C, Lohmann V. Hepatology. 2013 Mar;57(3):953-63

Low oxygen tension enhances hepatitis C virus replication.Vassilaki N, Kalliampakou KI, Kotta-Loizou I, Befani C, Liakos P, Simos G, Mentis AF, Kalliaropoulos A, Doumba PP, Smirlis D, Foka P, Bauhofer O, Poenisch M, Windisch MP, Lee ME, Koskinas J, Bartenschlager R, Mavromara P. J Virol. 2013 Mar;87(5):2935-48.

© Dep. of Infectious Diseases, Molecular Virology. University of Heidelberg
NEWS
26.11.2015
Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus.Bender S, Reuter A, Eberle F, Einhorn E, Binder M, Bartenschlager R. PLoS Pathog. 2015 Nov 20;11(11):e1005264.

Virus-specific CD4+ T Cells Have Functional and Phenotypic Characteristics of Follicular T-helper Cells in Patients With Acute and Chronic HCV Infections. Raziorrouh B, Sacher K, Tawar RG, Emmerich F, Neumann-Haefelin C, Baumert TF, Thimme R, Boettler T. Gastroenterology. 2015 Nov 13. pii: S0016-5085(15)01622-4.

Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor. Lempp FA, Mutz P, Lipps C, Wirth D, Bartenschlager R, Urban S. J Hepatol. 2015 Nov 11. pii: S0168-8278(15)00736-9. doi: 10.1016/j.jhep.2015.10.030. [Epub ahead of print]