Individual Projects

TP 1 (R. Bartenschlager)
Virological and immunological mechanisms of hepatitis C virus persistence

TP 2 (R. Thimme)
Immunopathogenesis of hepatitis B virus and hepatitis C virus infection

TP 3 (V. Lohmann)
Mechanisms of immune evasion by hepatitis C virus and their role in establishment of viral persistence

TP 4 (V. Brass/ D. Moradpour)
Impact of HBV-HCV coinfection on virus-specific cytotoxic T-cell responses and viral persistence

TP 5 (S. Urban)
Mechanisms of Hepatitis B virus X-protein (HBx)-mediated regulation of viral transcription in authentic cell culture systems

TP 6 (M. Nassal)
Cellular DNA repair in cccDNA formation during hepatitis B virus infection - addressing functionally redundant repair pathways

TP 7 (U. Klingmüller/ J. Timmer)
Addressing the multi-factorial impact on viral persistence by integrative dynamic pathway modeling

TP 8 (C. Neumann-Haefelin)
Protective CD8+ T cell responses and role of viral escape in HBV infection
© Dep. of Infectious Diseases, Molecular Virology. University of Heidelberg
Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus.Bender S, Reuter A, Eberle F, Einhorn E, Binder M, Bartenschlager R. PLoS Pathog. 2015 Nov 20;11(11):e1005264.

Virus-specific CD4+ T Cells Have Functional and Phenotypic Characteristics of Follicular T-helper Cells in Patients With Acute and Chronic HCV Infections. Raziorrouh B, Sacher K, Tawar RG, Emmerich F, Neumann-Haefelin C, Baumert TF, Thimme R, Boettler T. Gastroenterology. 2015 Nov 13. pii: S0016-5085(15)01622-4.

Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor. Lempp FA, Mutz P, Lipps C, Wirth D, Bartenschlager R, Urban S. J Hepatol. 2015 Nov 11. pii: S0168-8278(15)00736-9. doi: 10.1016/j.jhep.2015.10.030. [Epub ahead of print]