FOR 1202

Welcome to the homepage of the research unit 1202 (FOR 1202) „Mechanisms of persistence of hepatotropic viruses”.

This research unit is formed by scientists and clinicians from the Heidelberg University Hospital, the University Hospital Freiburg, the University of Freiburg and the German Cancer Research Center Heidelberg. FOR1202 aims at a detailed understanding of the mechanisms underlying intrinsic and adaptive resistance against persistent infections with the hepatitis B virus (HBV) and the hepatitis C virus (HCV). This research unit started in October 2009 and was extended upon positive re-evaluation in October 2012. The research unit is supported by a grant from the German Research Foundation (DFG).

Seven project teams have been united within this research unit with four projects carried out in Heidelberg by groups at the Department of Infectious Diseases, Molecular Virology belonging to the Heidelberg University Hospital, and at the German Cancer Research Center. Three groups are located in Freiburg at the Department of Medicine II at the University Hospital Freiburg and at the Institute of Physics at the University of Freiburg.

The central aim of FOR1202 is to decipher the molecular and immunological mechanisms leading to persistence of HBV and HCV infections. In order to meet this challenge, members of this research group have combined their expertise in the field of molecular and cell biology, immunology, biochemistry, virology, and systems biology. Results obtained from these fundamental studies should help to develop prophylactic vaccines and to improve therapy of patients that are chronically infected with these viruses.

Prof. Dr. Ralf Bartenschlager
Department of Infectious Diseases,
Molecular Virology
Heidelberg University Hospital
Prof. Dr. Robert Thimme Department of Medicine II University Hospital Freiburg

Project Coordinator and contact information
Dr. Sandra Bühler
Department of Infectious Diseases, Molecular Virology
Heidelberg University Hospital
Im Neuenheimer Feld 345
69120 Heidelberg

Tel.: +49-6221-56-4225
Fax.: +49-6221-56-4570

© Dep. of Infectious Diseases, Molecular Virology. University of Heidelberg
Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus.Bender S, Reuter A, Eberle F, Einhorn E, Binder M, Bartenschlager R. PLoS Pathog. 2015 Nov 20;11(11):e1005264.

Virus-specific CD4+ T Cells Have Functional and Phenotypic Characteristics of Follicular T-helper Cells in Patients With Acute and Chronic HCV Infections. Raziorrouh B, Sacher K, Tawar RG, Emmerich F, Neumann-Haefelin C, Baumert TF, Thimme R, Boettler T. Gastroenterology. 2015 Nov 13. pii: S0016-5085(15)01622-4.

Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor. Lempp FA, Mutz P, Lipps C, Wirth D, Bartenschlager R, Urban S. J Hepatol. 2015 Nov 11. pii: S0168-8278(15)00736-9. doi: 10.1016/j.jhep.2015.10.030. [Epub ahead of print]